Improved preparation of an amino acid type poly(ethylene glycol) derivative.

نویسندگان

  • Keiko Hojo
  • Yuichi Susuki
  • Masahiko Sasaki
  • Mitsuko Maeda
  • Timothy John Smith
  • Koichi Kawasaki
چکیده

An amino acid type poly(ethylene glycol) is a useful tool for preparation of a bi- or multivalent poly(ethylene glycol) hybrid of bioactive peptides, but synthesis is problematic. The amino acid type poly(ethylene glycol) was prepared from poly(oxyethylene)diglycolic acid followed by introduction of a fluorenylmethyloxycarbonyl group. The resulting product could be purified easily by LH-20 column chromatography and HPLC.

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 50 7  شماره 

صفحات  -

تاریخ انتشار 2002